Allelic variation in CRHR1 predisposes to panic disorder: evidence for biased fear processing
نویسندگان
چکیده
منابع مشابه
Allelic variation in CRHR1 predisposes to panic disorder by biasing towards fear
Corticotropin releasing hormone (CRH) is a major regulator of the hypothalamicpituitary-adrenal (HPA) axis. Binding to its receptor CRHR1 triggers the downstream release of cortisol, a hormone needed for regulation of stress responses. Biochemical, behavioral and genetic studies revealed CRHR1 as a possible candidate gene for mood and anxiety disorders. Here, we aimed to evaluate CRHR1 as a can...
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Major depressive disorder (MDD) and panic disorder (PD) are common and disabling medical disorders with stress and genetic components. Dysregulation of the stress response of the hypothalamic-pituitary-adrenal axis, including the corticotrophin-releasing hormone (CRH) signaling via primary receptors (CRHR1 and CRHR2), is considered to play a major role for onset and recurrence in MDD and PD. To...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2015
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2015.125